Distal femoral Giant cell tumour of bone: intra-lesional curettage and stabilisation
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Giant cell tumour of bone is a rare, benign primary bone tumour arising in the meta-epiphyseal region of bones in young adults.This tumour classically arises in the meta-epiphyseal region as a radiolucent lesion most commonly affecting the distal femur, proximal tibia, proximal humerus and distal radius.
Surgical treatment involves intralesional curettage with or without internal fixation or en-bloc resection and limb-salvage reconstruction. The decision on the type of surgical treatment to undertake in a patient with GCTB depends on a variety of factors including the Campanacci staging at diagnosis, articular involvement and anatomical location.
Denosumab has recently played a role in the management of GCTB but the optimal use of denosomab has yet to be identified. Denosumab is a monoclonal antibody to RANK ligand recommended as the first option in inoperable or metastatic GCTB. Denosumab has also been used pre-operatively to downstage tumours with large soft tissue extension to allow for less morbid surgery.
Author: Mr Jonathan Stevenson FRCS (Tr & Orth)
Institution: The Royal Orthopaedic Hospital ,Birmingham ,UK.
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Question 1 of 10
Side effects of denosumab include all of the following except which one?CorrectIncorrect
Question 2 of 10
Non-operative interventions may include all of the following except which one ?CorrectIncorrect
Question 3 of 10
Radiological differential diagnoses of Giant cell tumours of bone may include which one of the following?CorrectIncorrect
Question 4 of 10
Hunter’s canal (adductor canal/ subsartorial canal) contains which of the following structures?CorrectIncorrect
Question 5 of 10
Which one of the following statements is correct about the saphenous nerve?CorrectIncorrect
Question 6 of 10
The cortical window fragment is not replaced due to which one of the following reasons ?CorrectIncorrect
Question 7 of 10
The subvastus medialis approach enables adequate plate coverage to minimise the risk of infection withoutCorrectIncorrect
Question 8 of 10
Intralesional curettage of Campanacci stage 1 and 2 tumours has a recurrence rate of which one of the following ?CorrectIncorrect
Question 9 of 10
The use of what has proven to reduce the risk of recurrence following intralesional curettage?CorrectIncorrect
Question 10 of 10
The use of what has been shown to reduce the risk of local recurrence in Campanacci 3 GCTBs?CorrectIncorrect